The seAFOod Polyp Prevention Trial

Pharmacological Effects and Toxicogenetic Impacts of Omeprazole: Genomic Instability and Cancer.

Omeprazole (OME) is commonly used to treat gastrointestinal disorders. However, long-term use of OME can increase the risk of gastric cancer.

We aimed to characterize the pharmacological effects of OME and to correlate its adverse effects and toxicogenetic risks to the genomic instability mechanisms and cancer-based on database reports.

Thus, a search (till Aug 2019) was made in the PubMed, Scopus, and ScienceDirect with relevant keywords. Based on the study objective, we included 80 clinical reports, forty-six in vitro, and 76 in vivo studies. While controversial, the findings suggest that long-term use of OME (5 to 40 mg/kg) can induce genomic instability.

On the other hand, OME-mediated protective effects are well reported and related to proton pump blockade and anti-inflammatory activity through an increase in gastric flow, anti-inflammatory markers (COX-2 and interleukins) and antiapoptotic markers (caspases and BCL-2), glycoprotein expression, and neutrophil infiltration reduction.

SKT (KIAA1217) Antibody

abx234542-100ug 100 ug
EUR 610.8

SKT (KIAA1217) Antibody

abx234542-100g 100 µg
EUR 350

Mouse Skt ELISA Kit

EF014796 96tests
EUR 566

Mouse SKT shRNA Plasmid

20-abx980555
  • Ask for price
  • Ask for price
  • 150 µg
  • 300 µg

Mouse Sickle tail protein (SKT) ELISA Kit

abx389166-96tests 96 tests
EUR 1093.2

Mouse Sickle tail protein, Skt ELISA KIT

ELI-29595m 96tests
EUR 736

SKT (KIAA1217) (NM_019590) Human Over-expression Lysate

LS056243 100ug
EUR 960
Description: Transient overexpression lysate of KIAA1217 (KIAA1217), transcript variant 1

Recombinant Mouse Sickle tail protein (Skt) , partial

MBS1201914-INQUIRE INQUIRE Ask for price

Human Sickle tail protein homolog, SKT ELISA KIT

ELI-18163h 96tests
EUR 696

Recombinant Human Sickle tail protein homolog (SKT) , partial

MBS1296028-INQUIRE INQUIRE Ask for price

Leishmania (gp63) mouse monoclonal antibody, clone 96-126, Ascites

AM01176SU-N 500 µl Ask for price

Human beta-defensin 126 (BD126) ELISA Kit, 96 tests, Quantitative

100-285-BD126 1 Kit
EUR 1074

MAP126 (MAP-126, Microtubule-Associated Protein 126, MAP 126) (AP)

MBS6452763-01mL 0.1mL
EUR 895

MAP126 (MAP-126, Microtubule-Associated Protein 126, MAP 126) (AP)

MBS6452763-5x01mL 5x0.1mL
EUR 3875

MAP126 (MAP-126, Microtubule-Associated Protein 126, MAP 126) (APC)

MBS6452764-01mL 0.1mL
EUR 895

MAP126 (MAP-126, Microtubule-Associated Protein 126, MAP 126) (APC)

MBS6452764-5x01mL 5x0.1mL
EUR 3875

MAP126 (MAP-126, Microtubule-Associated Protein 126, MAP 126) (Biotin)

MBS6452765-01mL 0.1mL
EUR 895

MAP126 (MAP-126, Microtubule-Associated Protein 126, MAP 126) (Biotin)

MBS6452765-5x01mL 5x0.1mL
EUR 3875

MAP126 (MAP-126, Microtubule-Associated Protein 126, MAP 126) (FITC)

MBS6452766-01mL 0.1mL
EUR 895

MAP126 (MAP-126, Microtubule-Associated Protein 126, MAP 126) (FITC)

MBS6452766-5x01mL 5x0.1mL
EUR 3875

MAP126 (MAP-126, Microtubule-Associated Protein 126, MAP 126) (HRP)

MBS6452767-01mL 0.1mL
EUR 895

MAP126 (MAP-126, Microtubule-Associated Protein 126, MAP 126) (HRP)

MBS6452767-5x01mL 5x0.1mL
EUR 3875

MAP126 (MAP-126, Microtubule-Associated Protein 126, MAP 126) (PE)

MBS6452773-01mL 0.1mL
EUR 895

MAP126 (MAP-126, Microtubule-Associated Protein 126, MAP 126) (PE)

MBS6452773-5x01mL 5x0.1mL
EUR 3875

AG-126

C4338-10 10 mg
EUR 162
Description: ERK1 (p44) and ERK2 (p42) inhibitor

AG-126

C4338-25 25 mg
EUR 366
Description: ERK1 (p44) and ERK2 (p42) inhibitor

AG-126

C4338-5 5 mg
EUR 87
Description: ERK1 (p44) and ERK2 (p42) inhibitor

AG 126

524137 1.0mg
EUR 205

BF 126

T30437-10mg 10mg Ask for price
Description: BF 126

BF 126

T30437-1g 1g Ask for price
Description: BF 126

BF 126

T30437-1mg 1mg Ask for price
Description: BF 126

BF 126

T30437-50mg 50mg Ask for price
Description: BF 126

BF 126

T30437-5mg 5mg Ask for price
Description: BF 126

GSK-126

abx282902-100g 100 µg Ask for price

GSK-126

abx282902-20g 20 µg
EUR 143.75

GSK-126

abx282902-50g 50 µg
EUR 425

BF 126

MBS5780068-5mg 5(mg
EUR 915

BF 126

MBS5780068-5x5mg 5x5(mg
EUR 3970

AG-126

MBS3842121-100mg 100mg
EUR 845

AG-126

MBS3842121-10mg 10mg
EUR 190

AG-126

MBS3842121-50mg 50mg
EUR 475

AG-126

MBS3842121-5mg 5mg
EUR 145

AG-126

MBS3842121-5x100mg 5x100mg
EUR 3790

AG 126

MBS3607167-100mg 100mg
EUR 880

AG 126

MBS3607167-10mg 10mg
EUR 255

AG 126

MBS3607167-25mg 25mg
EUR 365

AG 126

MBS3607167-2mg 2mg
EUR 200

AG 126

MBS3607167-50mg 50mg
EUR 550

AG-126

MBS565527-25mg 25mg
EUR 590

AG-126

MBS565527-5mg 5mg
EUR 220

AG-126

MBS565527-5x25mg 5x25mg
EUR 2510

MAP126 (MAP-126, Microtubule-Associated Protein 126, MAP 126) (MaxLight 405)

MBS6452768-01mL 0.1mL
EUR 895

MAP126 (MAP-126, Microtubule-Associated Protein 126, MAP 126) (MaxLight 405)

MBS6452768-5x01mL 5x0.1mL
EUR 3875

MAP126 (MAP-126, Microtubule-Associated Protein 126, MAP 126) (MaxLight 490)

MBS6452769-01mL 0.1mL
EUR 895

MAP126 (MAP-126, Microtubule-Associated Protein 126, MAP 126) (MaxLight 490)

MBS6452769-5x01mL 5x0.1mL
EUR 3875

MAP126 (MAP-126, Microtubule-Associated Protein 126, MAP 126) (MaxLight 550)

MBS6452770-01mL 0.1mL
EUR 895

MAP126 (MAP-126, Microtubule-Associated Protein 126, MAP 126) (MaxLight 550)

MBS6452770-5x01mL 5x0.1mL
EUR 3875

MAP126 (MAP-126, Microtubule-Associated Protein 126, MAP 126) (MaxLight 650)

MBS6452771-01mL 0.1mL
EUR 895

MAP126 (MAP-126, Microtubule-Associated Protein 126, MAP 126) (MaxLight 650)

MBS6452771-5x01mL 5x0.1mL
EUR 3875

MAP126 (MAP-126, Microtubule-Associated Protein 126, MAP 126) (MaxLight 750)

MBS6452772-01mL 0.1mL
EUR 895

MAP126 (MAP-126, Microtubule-Associated Protein 126, MAP 126) (MaxLight 750)

MBS6452772-5x01mL 5x0.1mL
EUR 3875

CREB327 (113 - 126)

5-01003 4 x 5mg Ask for price

Beta-defensin 126

AP82027 1mg
EUR 2640

PrP (106-126)

HY-P0305 10mg
EUR 1695.6

Nucleoprotein (118-126)

HY-P1584 10mg
EUR 734.4

Nucleoprotein (118-126)

TP1077-10mg 10mg Ask for price
Description: Nucleoprotein (118-126)

Nucleoprotein (118-126)

TP1077-1g 1g Ask for price
Description: Nucleoprotein (118-126)

Nucleoprotein (118-126)

TP1077-1mg 1mg Ask for price
Description: Nucleoprotein (118-126)

Nucleoprotein (118-126)

TP1077-50mg 50mg Ask for price
Description: Nucleoprotein (118-126)

Nucleoprotein (118-126)

TP1077-5mg 5mg Ask for price
Description: Nucleoprotein (118-126)

Tyrphostin AG 126

MBS579990-10mg 10mg
EUR 190

Tyrphostin AG 126

MBS579990-25mg 25mg
EUR 300

Tyrphostin AG 126

MBS579990-2mg 2mg
EUR 145

Tyrphostin AG 126

MBS579990-50mg 50mg
EUR 480

Tyrphostin AG 126

MBS579990-5mg 5mg
EUR 155

CREB327 (113-126)

MBS8246382-10mg 10mg
EUR 640

CREB327 (113-126)

MBS8246382-1mg 1mg
EUR 245

CREB327 (113-126)

MBS8246382-5mg 5mg
EUR 455

CREB327 (113-126)

MBS8246382-5x10mg 5x10mg
EUR 2800

Aphrodisin (aa107-126)

MBS620930-002mL 0.02mL
EUR 455

Aphrodisin (aa107-126)

MBS620930-01mL 0.1mL
EUR 965

Aphrodisin (aa107-126)

MBS620930-5x01mL 5x0.1mL
EUR 4185

Nucleoprotein 118-126

MBS5763390-10mg 10mg
EUR 425

Nucleoprotein 118-126

MBS5763390-1mg 1mg
EUR 175

Nucleoprotein 118-126

MBS5763390-5mg 5mg
EUR 320

Nucleoprotein 118-126

MBS5763390-5x10mg 5x10mg
EUR 1765

miRZip-126-3p anti-miR-126-3p microRNA construct

MZIP126-3p-PA-1 Bacterial Streak
EUR 620

Prion Protein (106-126) / PrP (106-126) (Human, Monkey)

034-17 100 μg
EUR 250.56

PKG2 (Ab-126) Antibody

8B8173 50ug
EUR 368
Description: PKG2 (Ab-126) Antibody

PKG2 (Ab-126) Antibody

33249-100ul 100ul
EUR 302.4

PKG2 (Ab-126) Antibody

33249-50ul 50ul
EUR 224.4

BAD (103 - 126), human

5-00743 4 x 1mg Ask for price

CREB327 (113 126) Peptide

20-abx266454
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  • 10 mg
  • 25 mg
  • 5 mg

PKG2 (Ab-126) Antibody

E033249 100μg/100μl
EUR 255
Description: Available in various conjugation types.

PKG2 (Ab-126) Antibody

E11-8173B 100μg
EUR 225
Description: Available in various conjugation types.

PRKG2 (Ab-126) Antibody

CSB-PA843898- each
EUR 402
Description: A polyclonal antibody against PRKG2 (Ab-126). Recognizes PRKG2 (Ab-126) from Human, Mouse. This antibody is Unconjugated. Tested in the following application: ELISA, WB;WB:1:500-1:3000

PRKG2 (Ab-126) Antibody

CSB-PA843898-100ul 100ul
EUR 379.2
Description: A polyclonal antibody against PRKG2 (Ab-126). Recognizes PRKG2 (Ab-126) from Human, Mouse. This antibody is Unconjugated. Tested in the following application: ELISA, WB;WB:1:500-1:3000

Chicken MRP-126 ELISA

KT-1910 96 tests
EUR 595

Turtle MRP-126 ELISA

KT-1919 96 tests
EUR 595

Leptin (126-140) (human)

H-3492.0001 1.0mg
EUR 618
Description: Sum Formula: C65H103N15O26; CAS# [313220-09-6]

Leptin (126-140) (human)

H-3492.0005 5.0mg
EUR 2358
Description: Sum Formula: C65H103N15O26; CAS# [313220-09-6]

rno-miR-126 Primers

MP-r00092 150 ul / 10 uM
EUR 211.2

hsa-miR-126 Primers

MPH01082 150 ul / 10 uM
EUR 145.2

MRAP2c (78-126) (Human)

006-37 100 μg
EUR 300.24

ODAPH (74-126) (Mouse)

077-90 100 μg
EUR 428.76

BAD (103 126) Peptide

abx265120-10mg 10 mg
EUR 837.5

BAD (103 126) Peptide

abx265120-1mg 1 mg
EUR 250

BAD (103 126) Peptide

abx265120-5mg 5 mg
EUR 550

CREB327 (113 126) Peptide

abx266454-1ml 1 ml
EUR 525

CREB327 (113 126) Peptide

abx266454-200l 200 µl
EUR 350

Prion Peptide (106-126)

abx266853-1ml 1 ml
EUR 475

Prion Peptide (106-126)

abx266853-200l 200 µl
EUR 225

Influenza HA (126-138)

TP1735-10mg 10mg Ask for price
Description: Influenza HA (126-138)

Influenza HA (126-138)

TP1735-1g 1g Ask for price
Description: Influenza HA (126-138)

Influenza HA (126-138)

TP1735-1mg 1mg Ask for price
Description: Influenza HA (126-138)

Influenza HA (126-138)

TP1735-50mg 50mg Ask for price
Description: Influenza HA (126-138)

Influenza HA (126-138)

TP1735-5mg 5mg Ask for price
Description: Influenza HA (126-138)

Influenza HA (126-138)

MBS5789420-INQUIRE INQUIRE Ask for price

PRKG2 (Ab-126) Antibody

MBS7130625-01mL 0.1mL
EUR 270

PRKG2 (Ab-126) Antibody

MBS7130625-5x01mL 5x0.1mL
EUR 1200

PKG2 (Ab-126) Antibody

MBS9408757-005mL 0.05mL
EUR 245

PKG2 (Ab-126) Antibody

MBS9408757-01mL 0.1mL
EUR 305

PKG2 (Ab-126) Antibody

MBS9408757-5x01mL 5x0.1mL
EUR 1230

ANP (126-150) (Rat)

MBS8246105-10mg 10mg
EUR 1540

ANP (126-150) (Rat)

MBS8246105-1mg 1mg
EUR 475

ANP (126-150) (Rat)

MBS8246105-5mg 5mg
EUR 1065

ANP (126-150) (Rat)

MBS8246105-5x10mg 5x10mg
EUR 6855

BAD (103-126) (Human)

MBS8246135-10mg 10mg
EUR 1035

BAD (103-126) (Human)

MBS8246135-1mg 1mg
EUR 335

BAD (103-126) (Human)

MBS8246135-5mg 5mg
EUR 715

BAD (103-126) (Human)

MBS8246135-5x10mg 5x10mg
EUR 4575

PKG2 (Ab-126) Antibody

MBS855430-01mg 0.1mg
EUR 305

PKG2 (Ab-126) Antibody

MBS855430-01mLAF405L 0.1mL(AF405L)
EUR 465

PKG2 (Ab-126) Antibody

MBS855430-01mLAF405S 0.1mL(AF405S)
EUR 465

PKG2 (Ab-126) Antibody

MBS855430-01mLAF610 0.1mL(AF610)
EUR 465

PKG2 (Ab-126) Antibody

MBS855430-01mLAF635 0.1mL(AF635)
EUR 465

Ba71V-126 Antibody Pair

MBS9018932-1PairSufficientfor5x96wellplates 1Pair(Sufficientfor5x96wellplates)
EUR 775

Ba71V-126 Antibody Pair

MBS9018932-5x1PairSufficientfor25x96wellplates 5x1Pair(Sufficientfor25x96wellplates)
EUR 3475

Histone H2B, aa118-126

MBS621287-02mg 0.2mg
EUR 870

Histone H2B, aa118-126

MBS621287-5x02mg 5x0.2mg
EUR 3765

Profilin (a.a. 126-137)

MBS474133-01mL 0.1mL
EUR 370

Profilin (a.a. 126-137)

MBS474133-5x01mL 5x0.1mL
EUR 1505

mKO2- SLBP (18- 126)

PVT10348 2ug
EUR 182

Prion Peptide (106-126), Human

5-01808 4 x 1mg Ask for price

Urodilatin CCC/ANP-95-126

5-02059 4 x 1mg Ask for price

Cyclin B1 (Ab-126) Antibody

8B0068 50ug
EUR 368
Description: Cyclin B1 (Ab-126) Antibody

Defensin Beta 126 (DEFb126) Antibody

20-abx129071
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  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

FGF basic (119-126) Peptide

20-abx265341
  • Ask for price
  • Ask for price
  • Ask for price
  • 10 mg
  • 25 mg
  • 5 mg

Atrial Natriuretic Peptide (126-149)

20-abx265678
  • Ask for price
  • Ask for price
  • Ask for price
  • 0.5 mg
  • 1 mg
  • 2.5 mg

Atrial Natriuretic Peptide (126-150)

20-abx265679
  • Ask for price
  • Ask for price
  • Ask for price
  • 0.5 mg
  • 1 mg
  • 2.5 mg

Defensin Beta 126 (DEFb126) Antibody

20-abx172068
  • Ask for price
  • Ask for price
  • 1 mg
  • 200 ug

Defensin Beta 126 (DEFB126) Antibody

20-abx333959
  • Ask for price
  • Ask for price
  • Ask for price
  • Ask for price
  • Ask for price
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Beta-Defensin 126 (DEFB126) Antibody

20-abx319593
  • Ask for price
  • Ask for price
  • Ask for price
  • Ask for price
  • Ask for price
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Recombinant Chicken Protein MRP-126

CSB-YP326790CH 9063 mg Ask for price

Cyclin B1 (Ab-126) Antibody

E11-0068B 100μg/100μl
EUR 225
Description: Available in various conjugation types.

Polyclonal NXPH1 Antibody (aa77-126)

AMM06874G 0.05ml
EUR 580.8
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human NXPH1 (aa77-126). This antibody is tested and proven to work in the following applications:

Prion Protein 106-126 (human)

B5433-.5 500 µg
EUR 301.2

Prion Protein 106-126 (human)

B5433-1 1 mg
EUR 302
Description: Prion peptide fragment that exhibits neurotoxicity

PKG2 (Ab-126) Conjugated Antibody

C33249 100ul
EUR 476.4

Recombinant Chicken Protein MRP-126

MBS1063159-002mgBaculovirus 0.02mg(Baculovirus)
EUR 1040

Recombinant Chicken Protein MRP-126

MBS1063159-002mgEColi 0.02mg(E-Coli)
EUR 620

Recombinant Chicken Protein MRP-126

MBS1063159-002mgYeast 0.02mg(Yeast)
EUR 795

Recombinant Chicken Protein MRP-126

MBS1063159-01mgEColi 0.1mg(E-Coli)
EUR 720

Recombinant Chicken Protein MRP-126

MBS1063159-01mgYeast 0.1mg(Yeast)
EUR 930

Prion Protein (106-126) (human)

H-1566.0500 0.5mg
EUR 327.6
Description: Sum Formula: C80H138N26O24S2; CAS# [148439-49-0] net

Prion Protein (106-126) (human)

H-1566.1000 1.0mg
EUR 501.6
Description: Sum Formula: C80H138N26O24S2; CAS# [148439-49-0] net

rno??miR-126 miRNA Antagomir

MNR01065 2 x 5.0 nmol
EUR 394.8

rno??miR-126 miRNA Inhibitor

MIR01065 2 x 5.0 nmol
EUR 211.2

hsa-miR-126 miRNA Antagomir

MNH01159 2 x 5.0 nmol
EUR 394.8

hsa-miR-126 miRNA Inhibitor

MIH01159 2 x 5.0 nmol
EUR 211.2

mmu-miR-126-3p Primers

MPM00053 150 ul / 10 uM
EUR 145.2

mmu-miR-126-5p Primers

MPM00056 150 ul / 10 uM
EUR 145.2

hsa-miR-126-3p Primers

MPH02124 150 ul / 10 uM
EUR 145.2

hsa-miR-126-5p Primers

MPH02125 150 ul / 10 uM
EUR 145.2

Recombinant Defensin Beta 126 (DEFb126)

RPQ483Hu01 10ug
EUR 168

Recombinant Defensin Beta 126 (DEFb126)

RPU52372-100ug 100ug
EUR 517

Recombinant Defensin Beta 126 (DEFb126)

RPU52372-1mg 1mg
EUR 2293.2

Recombinant Defensin Beta 126 (DEFb126)

RPU52372-50ug 50ug
EUR 415.8

Defensin Beta 126 (DEFb126) Antibody

abx129071-100l 100 µl
EUR 287.5

Defensin Beta 126 (DEFb126) Antibody

abx129071-1ml 1 ml
EUR 825

Defensin Beta 126 (DEFb126) Antibody

abx129071-200l 200 µl
EUR 362.5

Defensin Beta 126 (DEFb126) Antibody

abx172068-100l 100 µl
EUR 875

Defensin Beta 126 (DEFb126) Antibody

abx172068-1ml 1 ml Ask for price

Defensin Beta 126 (DEFb126) Antibody

abx172068-200l 200 µl Ask for price

ANP (95-126) / Urodilatin (Human)

005-18 200 μg
EUR 177.12

FGF basic (119-126) Peptide

abx265341-1mg 1 mg
EUR 225

Atrial Natriuretic Peptide (126-149)

abx265678-100tests 100 tests
EUR 437.5

Atrial Natriuretic Peptide (126-149)

abx265678-200tests 200 tests
EUR 700

Atrial Natriuretic Peptide (126-149)

abx265678-500tests 500 tests Ask for price

Atrial Natriuretic Peptide (126-150)

abx265679-200tests 200 tests
EUR 437.5

The reported adverse and toxic effects, especially in clinical studies, were atrophic gastritis, cobalamin deficiencies, homeostasis disorders, polyp development, hepatotoxicity, cytotoxicity, and genotoxicity. This study highlights that OME may induce genomic instability and increase the risk of certain types of cancer. Therefore, adequate precautions should be taken, especially in its long-term therapeutic strategies and self-medication practices.